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Serum iron and mental status changes: when people are anemic they can feel kind of low, sluggish. That’s one of the symptoms of iron-deficiency anemia. The whole gestalt of this is a person comes in with psychiatric symptoms. “I feel confused, I feel anxious. My husband is confused.” The first thing we want to do is rule out a general medical condition that we can reverse. Like, “Oh, your magnesium is low” or “Oh, you are not getting enough iron because you’ve got this bad GI bleed going on” or “Oh, your thyroid is off.” Once we’ve done all of that we say, “Okay, you’re not going to die. Go to the psychiatrist and he’ll give you some psychiatric medication.” Now even though the psychiatric condition, the schizophrenia, the depression, is very biological, it’s very medical. Here we are at the end of the 20th century and we don’t have a neat little test that we can say, “Okay, you have schizophrenia because it showed up on our PET scan”. We are there experimentally but we are not there clinically. In 100 years you’ll probably be able to send most psychiatric patients, I’m thinking, to the lab or the radiologist and he will say, “Yes, here’s your psychiatric diagnosis. This is schizophrenia, this is manic depression.” But basically those are all still clinical diagnoses.
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Hypokalemia: one of those is because of poor nutrition and another is eating disorders. These bulimic women - and believe me, it tends to be a disease of women - will vomit, will make themselves vomit and then they will get hypokalemic. Also, here’s a trivia question. There’s also a certain type of food that, if you eat a lot of, will cause hypokalemia. Does anyone know what that is? Licorice. Yeah, certain types of black licorice will cause hypokalemia. Every once in awhile you will see this case report and you’ve got this poor, young bulimic who loves to binge on licorice. She is just eating strands and strands of black licorice and then throwing it up, and her potassium is in the basement as a result of that.
EKG abnormalities: thioridazine can cause quinidine-like effects, such as prolonged TP and CR intervals. That’s important to know. Mellaril, or thioridazine, that is the least heart-healthy of your antipsychotics probably. Lithium can cause T-wave flattening or inversion. Looks like hypokalemia. TCA overdose, classically QRS widening and anorexia can result in bradycardia or other arrhythmias. Kind of another neat point is sometimes what you will see on psychiatric units, a common cause of bradycardia - mild bradycardia - is nicotine withdrawal. Now hospitals are all non-smoking, including psychiatric units and you’ll see these people - they’ll have a slow heart rate sometimes. Most substances, when you withdraw, you get tachycardic, as you know. Nicotine is the reverse of this. It’s kind of paradoxical. The heart rate can slow down.
There is one where you’ve got to get an EKG. Lithium, no question. You want an EKG. There were a few tragic deaths with one of the TCAs, desipramine I believe. There were a few kids who died unfortunately, in a relatively short period of time, because they were put on desipramine. There were like six kids cialis professional and in a short period of time three of them died and three of them, I guess, lived. But they had fatal arrhythmias from desipramine. So in pediatric populations we like to get EKG’s. But in your young, healthy adult - let’s say somebody comes in for pain - “Hey doc, I’ve got headache.” You are going to put them on Elavil, amitriptyline - which I’m assuming is still used by neurologists for pain. Probably not. It’s always nice to get an EKG but I don’t think most people would say this is mandatory to get an EKG. Anybody with heart block is at risk for having a TCA, so it’s nice to have an EKG but I don’t think it’s standard of care like it is with lithium.
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